{"id":5327,"date":"2024-01-16T09:44:17","date_gmt":"2024-01-16T08:44:17","guid":{"rendered":"https:\/\/zoe4life.org\/?post_type=projets-de-recherche&#038;p=5327"},"modified":"2024-01-16T09:47:40","modified_gmt":"2024-01-16T08:47:40","slug":"inform2-nivent-a-clinical-study-for-children-with-relapsed-cancer-2","status":"publish","type":"projets-de-recherche","link":"https:\/\/zoe4life.org\/en\/research-projects\/inform2-nivent-a-clinical-study-for-children-with-relapsed-cancer-2\/","title":{"rendered":"INFORM2 NivEnt: a clinical trial for children with relapsing cancer"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"5327\" class=\"elementor elementor-5327\" data-elementor-post-type=\"projets-de-recherche\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cd2513d e-con-full e-flex e-con e-parent\" data-id=\"cd2513d\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_bottom&quot;:&quot;curve&quot;,&quot;shape_divider_bottom_negative&quot;:&quot;yes&quot;}\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"true\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M500,97C126.7,96.3,0.8,19.8,0,0v100l1000,0V1C1000,19.4,873.3,97.8,500,97z\"\/>\n<\/svg>\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3b37b86 e-con-full e-flex e-con e-child\" data-id=\"3b37b86\" data-element_type=\"container\" data-settings=\"{&quot;shape_divider_bottom&quot;:&quot;curve&quot;,&quot;shape_divider_bottom_negative&quot;:&quot;yes&quot;,&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"true\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M500,97C126.7,96.3,0.8,19.8,0,0v100l1000,0V1C1000,19.4,873.3,97.8,500,97z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c81153f e-flex e-con-boxed e-con e-parent\" data-id=\"c81153f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-001fe7e elementor-widget elementor-widget-heading\" data-id=\"001fe7e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\"><span>INFORM2<\/span> NivEnt: a clinical study for children with relapsing cancer<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8d6d5d8 e-flex e-con-boxed e-con e-parent\" data-id=\"8d6d5d8\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4707128 elementor-widget elementor-widget-heading\" data-id=\"4707128\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The INFORM2 NivEnt study, an innovative targeted treatment for cancer resistant to conventional therapies<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3af7dde elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"3af7dde\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Some children suffer from recurrent and refractory cancer for whom conventional anti-tumor therapies are no longer effective. This is why the INFORM2 NivEnt study is testing a combination of two new drugs in some of these children:<\/p><ul><li>Nivolumab: not only does it prevent cancer cells from hiding from the immune system, it also helps the immune system to attack cancer cells.<\/li><li>Entinostat: modifies the structure of gene molecules in cancer cells to halt tumor growth.<\/li><\/ul><p>In laboratory experiments with tumor cells, these drugs work particularly well when combined. However, this combination has not yet been evaluated in humans.<\/p><p><strong>In the INFORM2 NivEnt study, patients were treated with both drugs.  Efficacy against the disease has been established.<\/strong><\/p><p>Complementary research will also be carried out. The aim is to understand how different groups of patients react according to the biological characteristics of their tumor.<\/p><p>For further information, please consult\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32503469\/\" target=\"_blank\" rel=\"noopener\">medical journal about INFORM2 NivEnt.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22696c0 elementor-widget elementor-widget-heading\" data-id=\"22696c0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Zo\u00e94life has funded INFORM2 NivEnt to the tune of CHF 62,700.-, thanks to funds raised at our Move4life event in March 2021.\nThis therapy will soon be available for children in Switzerland.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5f719c3 e-con-full e-flex e-con e-parent\" data-id=\"5f719c3\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-f6d49df e-flex e-con-boxed e-con e-child\" data-id=\"f6d49df\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;background_motion_fx_motion_fx_scrolling&quot;:&quot;yes&quot;,&quot;background_motion_fx_translateY_effect&quot;:&quot;yes&quot;,&quot;background_motion_fx_range&quot;:&quot;viewport&quot;,&quot;background_motion_fx_translateY_direction&quot;:&quot;negative&quot;,&quot;background_motion_fx_translateY_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:4,&quot;sizes&quot;:[]},&quot;background_motion_fx_translateY_affectedRange&quot;:{&quot;unit&quot;:&quot;%&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:{&quot;start&quot;:0,&quot;end&quot;:100}},&quot;background_motion_fx_devices&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile_extra&quot;,&quot;mobile&quot;]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8efe5df e-flex e-con-boxed e-con e-child\" data-id=\"8efe5df\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-08d15d3 elementor-widget-mobile__width-initial elementor-widget__width-initial elementor-widget-mobile_extra__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"08d15d3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our other actions :<\/p><p><a class=\"button white is-link expand\" href=\"https:\/\/zoe4life.org\/en\/research-and-new-treatments\/\">RESEARCH AND NEW TREATMENTS<\/a><\/p><p><a class=\"button white is-link expand\" href=\"https:\/\/zoe4life.org\/en\/family-support\/\">FAMILY SUPPORT<\/a><\/p><p><a class=\"button white is-link expand no-margin no-padding\" href=\"https:\/\/zoe4life.org\/en\/projects-for-children\/\">PROJECTS FOR CHILDREN<\/a><\/p><p><a class=\"button white is-link expand no-margin no-padding\" href=\"https:\/\/zoe4life.org\/en\/sensibiliser-cancer-enfant\/\" target=\"_self\">PUBLIC AWARENESS\u00a0<i class=\"icon-angle-right\"><\/i><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cf2bf9e e-flex e-con-boxed e-con e-parent\" data-id=\"cf2bf9e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d99401b e-flex e-con-boxed e-con e-child\" data-id=\"d99401b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-43cbaaf elementor-widget elementor-widget-image\" data-id=\"43cbaaf\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"629\" height=\"848\" src=\"https:\/\/zoe4life.org\/wp-content\/uploads\/2023\/10\/poupee-baskets.png\" class=\"attachment-large size-large wp-image-751\" alt=\"\" srcset=\"https:\/\/zoe4life.org\/wp-content\/uploads\/2023\/10\/poupee-baskets.png 629w, https:\/\/zoe4life.org\/wp-content\/uploads\/2023\/10\/poupee-baskets-223x300.png 223w\" sizes=\"(max-width: 629px) 100vw, 629px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-57d362b e-flex e-con-boxed e-con e-child\" data-id=\"57d362b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0575c28 elementor-widget elementor-widget-heading\" data-id=\"0575c28\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\"><span>Together<\/span> we can make a difference<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a2ebdf elementor-widget elementor-widget-text-editor\" data-id=\"7a2ebdf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>There are many ways to support us. Your commitment makes a difference for children with cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5bd954e elementor-align-left elementor-widget elementor-widget-global elementor-global-4109 elementor-widget-button\" data-id=\"5bd954e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pay.raisenow.io\/btpnw?lng=fr\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"Calque_1\" x=\"0px\" y=\"0px\" viewbox=\"0 0 50 50\" style=\"enable-background:new 0 0 50 50;\" xml:space=\"preserve\">    <style type=\"text\/css\">\t.st001{fill:#FFFFFF;}\t.st1112{fill:url(#Shape2_00000178191402229356023940000015828331205161406142_);}\t.st2222{fill:url(#SVGID_4_);}<\/style>    <g>        <path id=\"Shape1\" class=\"st001\" d=\"M46,36c0,0.6-0.4,1.4-1,1.7l-19,11c-0.5,0.3-1.4,0.3-2,0l-19-11c-0.5-0.3-1-1.1-1-1.7V14  c0-0.6,0.4-1.4,1-1.7l19-11c0.5-0.3,1.4-0.3,2,0l19,11c0.5,0.3,1,1.1,1,1.7V36z\"><\/path>        <radialgradient id=\"Shape2_00000024724280133459020410000000180975724327773335_\" cx=\"2.6904\" cy=\"50.6259\" r=\"3.3483\" gradienttransform=\"matrix(6.848 0 0 -7.73 5.1131 408.0078)\" gradientunits=\"userSpaceOnUse\">            <stop offset=\"0\" style=\"stop-color:#FFCC00\"><\/stop>            <stop offset=\"9.157000e-02\" style=\"stop-color:#FFC800\"><\/stop>            <stop offset=\"0.1739\" style=\"stop-color:#FFBD00\"><\/stop>            <stop offset=\"0.2528\" style=\"stop-color:#FFAB00\"><\/stop>            <stop offset=\"0.3295\" style=\"stop-color:#FF9100\"><\/stop>            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donation<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db55ea1 elementor-align-right elementor-widget elementor-widget-global elementor-global-4112 elementor-widget-button\" data-id=\"db55ea1\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/zoe4life.givingpage.org\/donation-fr\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Donate <br> <small>all payment methods 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