{"id":3461,"date":"2023-10-19T11:08:10","date_gmt":"2023-10-19T09:08:10","guid":{"rendered":"https:\/\/zoe4life.org\/?post_type=projets-de-recherche&p=3461"},"modified":"2023-10-25T14:35:41","modified_gmt":"2023-10-25T12:35:41","slug":"optimizing-immunotherapy-for-refractory-neuroblastoma","status":"publish","type":"projets-de-recherche","link":"https:\/\/zoe4life.org\/en\/research-projects\/optimizing-immunotherapy-for-refractory-neuroblastoma\/","title":{"rendered":"Optimizing immunotherapy for refractory neuroblastoma"},"content":{"rendered":"
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Optimizing immunotherapy for refractory neuroblastoma<\/span><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Zo\u00e94life has helped fund a study to optimize immunotherapy for refractory neuroblastoma.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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High-risk neuroblastoma is an aggressive pediatric cancer. Indeed, its cure rate is still very low. Refractory primary neuroblastoma is a form that resists most therapies.<\/p>

Researchers from Stanford University and UCL, led by the Dr Robbie Majzner <\/a>and the Prof John Anderson <\/a>are conducting a study to assess how to improve chemoimmunotherapy for patients with this type of neuroblastoma.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What is chemoimmunotherapy?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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This is a combination of chemotherapy and immunotherapy. The aim is to trigger a patient's immune response to neuroblastoma cells.<\/p>

Anti-GD2 antibodies have been one of the major clinical breakthroughs of recent years. This form of immunotherapy has increased survival rates.<\/p>

Indeed, the combination of existing chemotherapeutic agents with anti-GD2 drugs has led to a good clinical response in children whose disease does not respond to chemotherapy alone.<\/p>

The advantage of this treatment is that it does not rely on destroying tumour cells with specific drugs. Instead, it helps the immune system to kill the cells.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Aim of the study:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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In conclusion, the aim of this study is to find treatments for children diagnosed with refractory primary neuroblastoma. These children currently have very few options for innovative treatments.<\/p>

The development of a clinical trial specific to this disease subtype will be revolutionary for this high-priority group of patients. What's more, the treatment will make it possible to eradicate ineffective toxic chemotherapies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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This project is part of our\ninternational partnership with Solving Kid's Cancer, Joining Against Cancer in Kids (J-A-C-K), Merryn Lacy Trust, Oscar Knox Fund, Rupert's Revenge.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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In conclusion, the aim of this study is to find treatments for children diagnosed with refractory primary neuroblastoma. These children currently have very few options for innovative treatments.<\/p>

The development of a clinical trial specific to this disease subtype will be revolutionary for this high-priority group of patients. What's more, the treatment will make it possible to eradicate ineffective toxic chemotherapies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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The latter was funded to the tune of \u00a3500,000, including \u00a3100,000 by Zo\u00e94life.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Find out more<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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HOW DOES IT WORK? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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This works by exploiting the mechanism by which neuroblastoma survives in the body at the molecular level.<\/p>

Neuroblastoma cells have molecules on their surface called GD2 and CD47. These trick the immune system into not destroying them by sending out \"don't eat me\" signals.<\/p>

The team plans to conduct preclinical studies to optimize current anti-GD2 chemoimmunotherapy and introduce a novel anti-CD47 agent into this regimen. This is in the hope of blocking the \"don't eat me\" signal and activating the \"eat me\" signals.<\/p>

This will enable the immune cells to function as they should and destroy the neuroblastoma cells.<\/p>

The ultimate goal is to build a successful combination therapy with chemotherapy, anti-GD2 agents and anti-CD47 agents that can be submitted to a clinical trial.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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